As reported in the Adelaide Sunday Mail page 09, a new use has been found for this enzyme by Medical Research Professor David Morris with fellow researchers Ahmed Mekkawy and Javed Akhter at the St George Hospital Laboratory.
It has been found that the Enzyme, together with another compound Acetylcysteine, dissolves the bonds that stabilise the spikes on the Coronavirus. Thus the virus cannot dock onto a cell and infect other cells. The new drug is called BromAc. Initially designed by Professor Morris for treating some cancers, the drug has been repurposed for use as a nasal spray which will hopefully, after more testing, show that the drug will dissolve the spike proteins the COVID -19 virus uses to infect cells.
To background this a little more, researchers noticed that pigs who were given pineapple residue as fodder did not get some gastrointestinal problems like parasites and other infections. These infections rely on attaching to glycoproteins ( a protective mucous ) to spread through the pig’s body. It was observed that many gastrointestinal cancers produce Gycloprotein mucous, which helps the cancers grow by protecting them from the immune system surveillance system. Professor Morris discovered in his experiments that when BromAc is used, this broke the bonds in the mucous and fell apart. He also observed that spikes on the Carona-19 virus were made of glycoproteins, and these too would be susceptible to the drug. Thus, a nasal spray was developed for testing that could prevent the virus from entering the Respiratory system.
Experiments are ongoing and look favourable to date as there seem to be minor side effects on using the spray.
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